research - bioanalytical

Our group is focused on all things electrochemical.  Fundamentals, applications, instrumentation.  Some recent areas of interest are shown below.  Highlights below are examples of our work, the full scope is much wider, please browse our publications for a full view.

psicm

Scanning Ion Conductance Microscopy at Interfaces

SICM is a useful tool for measuring ions in biological settings.  We have developed methods to use SICM to probe conductance at tissue monolayers where contributions from cell-cell contacts can be measured at subcellular scales.  For example, we have recently applied this appraoch to measuring tricellular junctions, showing discrete conductance changes that depend on osmotic stress (Chemical Science, 2020). 

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icp

Ion Channels and SICM

Ion channels can be used to incorporate selectivity into SICM measurements.  We have used a variety of channel types and a unique approach using double barrel tips to integrate imaging and chemical sensing at the nanoscale (Small, 2017). 

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rbc

Monitoring Membrane Processes with SICM

SICM can be used to monitor dynamic processes at biological membranes.  We have used this to follow spiculation in erythrocytes (Analyst, 2018).  We use similar approaches to follow changes in cell morphology and cell stiffness with SICM as well. 

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ms-sampling

Sampling with Nanopipettes for Mass Spectormetry

Nanopipettes are useful for sampling and analysis at scales commensurate with single-cell and even subcellular measurements.  We have reported a number of ways to accomplish this, including novel applications of dual barrel pipettes that can sample and hold analytes from biological interfaces. (Analyst, 2017).

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